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IMPACT OF FUNDED RESEARCH: Individual Grants

We have awarded $6 million since December 2004 to investigators working on promising CLL projects. The projects look at a variety of important CLL aspects:

BIOLOGY
GENETICS
IMMUNOLOGY
THERAPY/ PROGNOSTIC
SUPPORTIVE CARE

BIOLOGY

Burger

Microenvironmental regulation of survival and growth of B lymphocytes from patients with Chronic Lymphocytic Leukemia (CLL)
Jan Burger, M.D., Ph.D.
University of Texas M. D. Anderson Cancer Center

 

 

Chiorazzi

Characterization of the Proliferating Compartment in B-CLL Patients and in Healthy Aging Subjects
Nicholas Chiorazzi, M.D.
The Feinstein Institute for Medical Research

   

Deaglio

CD38 and the fate of CLL cells: innocent bystander or culprit?
Silvia Deaglio M.D.
University of Torino, Medical School (Italy)

   

Estrov

Role of STAT-3 in Serine Phosphorylation
Zeev Estrov, M.D.
University of Texas M. D. Anderson Cancer Center

   

Vega

Identification and Characterization of Tumor Initiating Cells in Chronic Lymphocytic Leukemia
Francisco Vega M.D., Ph.D.
University of Texas M. D. Anderson Cancer Center

   

GENETICS

Calin

Roles of microRNA in familial chronic lymphocytic leukemia
George Calin, M.D., Ph.D.
Ohio State University/ University of Texas M. D. Anderson Cancer Center

 

 

Dearden

A study of the poor prognostic genomic alterations affecting 11q and 17p in CLL using CGH arrays
Claire Dearden, M.D.
Royal Marsden Hospital/Institute of Cancer Research (United Kingdom)

   

Garcia-Manero

Epigenetic and therapeutic profiling of chronic lymphocytic leukemia
Guillermo Garcia-Manero, M.D.
University of Texas M. D. Anderson Cancer Center

   

Ghia

Dissecting CLL heterogeneity by proteomic analysis
Paolo Ghia, M.D., Ph.D.
Instituto Scientifico San Raffaele (Italy)

   

Jones

Proteomic characterization of activation induced TCL1-complexes and their targeting as a therapeutic strategy in CLL
Daniel Jones, M.D., Ph.D
University of Texas M. D. Anderson Cancer Center

   

Sampath

Transcriptional activation to target CLL
Deepa Sampath, Ph.D.
University of Texas M. D. Anderson Cancer Center

   

Tanner

Genetic and epigenetic pathways in CLL
Stephan M. Tanner, Ph.D.
The Ohio State University

   

IMMUNOLOGY

Gribben

Targeting CLL antigens after stem cell transplantation
John Gribben, M.D., DSc.
Barts Cancer Center of Excellence/ The London School of Medicine (United Kingdom)

 

 

Muligan

Global phenotype profiling of chronic lymphocytic leukemia
Stephen Mulligan, M.B., B.S., Ph.D.
University of Sydney (Australia)

   

Weirda

Immunotherapy with ISF35-Transduced Autologous CLL B Cells
William Wierda, M.D., Ph.D.
University of Texas M. D. Anderson Cancer Center

   

THERAPY/PROGNOSTIC

Abruzzo

Validation of Prognostic Biomarkers in CLL
Lynne Abruzzo, M.D., Ph.D.
University of Texas M. D. Anderson Cancer Center

 

 

Castro

Targeting ZAP-70 Tyrosine Kinase in Chronic Lymphocytic Leukemia
Januario Castro, M.D.
University of California, San Diego

   

Davis

Potential Role of FCRL2 as a Surrogate Marker of IgVH Mutation in CLL
Randall S. Davis, M.D.
University of Alabama at Birmingham

   

Dobrovic

Identifying Therapeutic Targets by Profiling DNA repair in CLL
Alexander Dobrovic, PhD
Peter MacCallum Cancer Centre (Australia)

   

Gandhi

Transcription Inhibition to Target CLL
Varsha Gandhi, Ph.D.
University of Texas M. D. Anderson Cancer Center

   

Hallek

Targeting Src-family kinases (SFKs) by membrane-permeant peptides
Michael Hallek, M.D.
University Cologne (Germany)

   

Houlston

Identification of Germline Variants Influencing the Clinical Expression of Chronic Lymphocytic Leukemia
Richard Houlston, M.D., Ph.D.
Institute of Cancer Research (United Kingdom)

   

Huang

Development of Glycolycin as a novel therapeutic
Peng Huang, M.D., Ph.D.
University of Texas M. D. Anderson Cancer Center

   

Huang

Pre-Clinical Studies of PEITC as a Novel Agent for Treatment of CLL
Peng Huang, M.D., Ph.D.
University of Texas M. D. Anderson Cancer Center

   

Kay

A Phase I/II Study of Oral green Tea Extract in Asymptomatic Rai Stage 0-II Patients with Chronic Lymphocytic Leukemia
Neil Kay, M.D
Mayo Clinic

   

Mukherjee

Application of gold nanoparticles in the treatment of B-Chronic Lymphocytic Leukemia (CLL)?
Priyabrata Mukherjee, Ph.D.
Mayo Clinic

   

Oscier

ZAP-70 methylation: a new prognostic marker in CLL
David Oscier, M.D.
Royal Bournemouth Hospital (United Kingdom)

   

Pekarsky

MicroRNAs targeting TCL1 as therapeutic agents for B-CLL
Yuri Pekarsky, Ph.D.
Ohio State University

   

Reed

Novel NF-κB Inhibitors for CLL Treatment
John C. Reed, M.D., Ph.D.
Burnham Institute for Medical Research

   

Stilgenbauer

Detailed analysis of cellular response mechanisms after chemotherapy and antibody treatment in biological CLL subgroups
Stephan Stilgenbauer, M.D.
University of Ulm (Germany)

   

SUPPORTIVE CARE

Kontoyiannis

Monitoring of Innate Cellular Immune Response in Chronic Lymphocytic Leukemia- A Pilot Study to Assess Patient Risk of Infection
Dimitrios Kontoyiannis, M.D.
University of Texas M. D. Anderson Cancer Center

 

 


 

 

 

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